Investigation of brain iron in anorexia nervosa, a quantitative susceptibility mapping study

P Ravanfar; RJ Rushmore; AE Lyall; V Cropley; N Makris; P Desmond; D Velakoulis; ME Shenton; AI Bush; SL Rossell; C Pantelis; WT Syeda; A Phillipou

Journal article

Investigation of brain iron in anorexia nervosa, a quantitative susceptibility mapping study

P Ravanfar, RJ Rushmore, AE Lyall, V Cropley, N Makris, P Desmond, D Velakoulis, ME Shenton, AI Bush, SL Rossell, C Pantelis, WT Syeda, A Phillipou

Journal of Eating Disorders | BMC | Published : 2023

DOI: 10.1186/s40337-023-00870-4

Abstract

Background: Anorexia nervosa (AN) is a potentially fatal psychiatric condition, associated with structural brain changes such as gray matter volume loss. The pathophysiological mechanisms for these changes are not yet fully understood. Iron is a crucial element in the development and function of the brain. Considering the systemic alterations in iron homeostasis in AN, we hypothesized that brain iron would be altered as a possible factor associated with structural brain changes in AN. Methods: In this study, we used quantitative susceptibility mapping (QSM) magnetic resonance imaging to investigate brain iron in current AN (c-AN) and weight-restored AN compared with healthy individuals. Whol..

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University of Melbourne Researchers

Vanessa Cropley Author

Patricia Desmond Author

Dennis Velakoulis Author

Ashley Bush Author

Related Projects (1)

TRANSLATING MEMBRANE PROTEINS INTO THERAPEUTICS; FROM BEDSIDE TO BENCH

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

The authors would like to thank all participants who took the time to participate in the study. This research was supported by the St Vincent's Hospital Research Endowment Fund and the Barbara Dicker Brain Sciences Foundation. A.P. was supported by a National Health and Medical Research Council (NHMRC) Project Grant (CIA: GNT1159953). S.L.R. holds an NHMRC Senior Research Fellowship (GNT1154651). C.P. was supported by an NHMRC L3 Investigator Grant (1196508) and NHMRC Program Grant (ID: 1150083). A.I.B. is supported by a NHMRC L3 Investigator Grant (1194028). V.L.C. is supported by a NHMRC Investigator Grant (1177370) and a University of Melbourne Dame Kate Campbell Fellowship. N.M. is supported by National Institute of Health (NIH) Grants: R01MH125860, R01MH112748, R01MH111917, K24MH116366, R01AG042512, R21DA042271. A.E.L. is supported by NIH grants NIMH 1K01MH115247-01A1 and 1K24MH110807-01A1, a Brain and Behavior Research Foundation Young Investigator Award and a Brigham and Women's Department of Psychiatry Internal Funding Award. R.J.R. is supported by NIMH grant R01MH112748. M.E.S. is supported by NIH grant 5 U01MH109977.